SKF-97,541

SKF-97,541.svg

SKF-97,541 is a chemical compound that acts as a selective dopamine reuptake inhibitor (DRI). It is primarily used in scientific research to study the dopamine system and its role in various neurological disorders.

Chemical Properties

SKF-97,541 has a molecular formula of C16H23NO2 and a molecular weight of 261.36 g/mol. It is a member of the piperidine class of compounds and is structurally related to other dopamine reuptake inhibitors.

Mechanism of Action

As a dopamine reuptake inhibitor, SKF-97,541 works by blocking the dopamine transporter (DAT), which is responsible for the reabsorption of dopamine from the synaptic cleft back into the presynaptic neuron. By inhibiting this transporter, SKF-97,541 increases the concentration of dopamine in the synaptic cleft, thereby enhancing dopaminergic neurotransmission.

Research Applications

SKF-97,541 is used in various research settings to investigate the role of dopamine in behavior, addiction, and psychiatric disorders. It is particularly useful in studies involving animal models of Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD).

Pharmacology

The pharmacological profile of SKF-97,541 includes high selectivity for the dopamine transporter over other monoamine transporters such as the serotonin transporter (SERT) and the norepinephrine transporter (NET). This selectivity makes it a valuable tool for isolating the effects of dopamine reuptake inhibition.

Safety and Toxicity

As with many research chemicals, the safety and toxicity profile of SKF-97,541 is not well-documented. It is typically handled with caution in laboratory settings, and its use is generally restricted to controlled environments.

See Also

• Dopamine reuptake inhibitor
• Dopamine transporter
• Neurological disorders
• Parkinson's disease
• Schizophrenia
• Attention deficit hyperactivity disorder

External Links

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