Sibrafiban

Sibrafiban_structure.svg

Sibrafiban is an investigational antiplatelet drug that was developed for the prevention of thrombotic events such as myocardial infarction and stroke. It belongs to the class of drugs known as glycoprotein IIb/IIIa inhibitors, which work by inhibiting the final common pathway for platelet aggregation.

Mechanism of Action

Sibrafiban functions by inhibiting the glycoprotein IIb/IIIa receptor on the surface of platelets. This receptor is crucial for the binding of fibrinogen and von Willebrand factor, which are essential for platelet aggregation and thrombus formation. By blocking this receptor, sibrafiban prevents the formation of blood clots.

Clinical Development

Sibrafiban was investigated in several clinical trials to assess its efficacy and safety in preventing thrombotic events. However, the development of sibrafiban was eventually discontinued due to concerns about its safety profile and the occurrence of adverse events in clinical trials.

Pharmacokinetics

The pharmacokinetics of sibrafiban involve its absorption, distribution, metabolism, and excretion. Sibrafiban is administered orally and is metabolized in the liver. The drug and its metabolites are excreted primarily through the kidneys.

Adverse Effects

Common adverse effects associated with sibrafiban include bleeding, thrombocytopenia, and gastrointestinal disturbances. Due to the risk of significant bleeding, the use of sibrafiban requires careful monitoring.

Conclusion

While sibrafiban showed promise as an antiplatelet agent, its development was halted due to safety concerns. The search for effective and safe antiplatelet therapies continues, with ongoing research into alternative agents.

See Also

• Antiplatelet drug
• Glycoprotein IIb/IIIa inhibitor
• Thrombosis
• Myocardial infarction
• Stroke

External Links

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