Spindle cell lipoma

Spindle_cell_lipoma.jpg

Spindle cell lipoma is a rare, benign tumor composed of adipose tissue and spindle-shaped cells. It typically occurs in the subcutaneous tissue of the neck, back, and shoulder regions. This type of lipoma is most commonly found in middle-aged to older adults, with a higher prevalence in males.

Presentation

Spindle cell lipomas usually present as slow-growing, painless masses. They are often well-circumscribed and can vary in size. The overlying skin is typically normal, and the tumor is usually mobile upon palpation.

Histopathology

Under the microscope, spindle cell lipomas are characterized by a mixture of mature adipocytes, bland spindle cells, and a myxoid stroma. The spindle cells are uniform and lack significant atypia. Collagen fibers are often present, and the tumor may show a ropey collagen pattern. Mitotic figures are rare, and there is no evidence of necrosis.

Diagnosis

The diagnosis of spindle cell lipoma is primarily based on histopathological examination. Immunohistochemistry can aid in the diagnosis, with spindle cells typically showing positivity for CD34 and negativity for S-100 protein. Magnetic resonance imaging (MRI) and computed tomography (CT) scans can be used to assess the extent of the tumor and its relationship to surrounding structures.

Differential Diagnosis

The differential diagnosis for spindle cell lipoma includes:

• Liposarcoma
• Neurofibroma
• Dermatofibrosarcoma protuberans
• Myxoid liposarcoma
• Fibromatosis

Treatment

The treatment of choice for spindle cell lipoma is surgical excision. Complete removal of the tumor is usually curative, and recurrence is rare. There is no need for chemotherapy or radiation therapy as spindle cell lipomas are benign.

Prognosis

The prognosis for patients with spindle cell lipoma is excellent. These tumors do not metastasize and have a very low recurrence rate following complete surgical excision.

See also

• Lipoma
• Adipose tissue
• Benign tumor
• Histopathology

References

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