Spindle cell rhabdomyosarcoma
Spindle cell rhabdomyosarcoma is a rare subtype of rhabdomyosarcoma, a type of cancer that develops from skeletal muscle cells. It is characterized by elongated, spindle-shaped cells, and is most commonly found in the head and neck, genitourinary tract, and retroperitoneum.
Epidemiology[edit | edit source]
Spindle cell rhabdomyosarcoma is a rare form of cancer, accounting for less than 3% of all rhabdomyosarcomas. It is most commonly diagnosed in children and young adults, but can occur at any age.
Pathology[edit | edit source]
The tumor is composed of elongated, spindle-shaped cells that resemble fibroblasts. These cells are arranged in a pattern that resembles a herringbone or fascicular pattern. The cells often express desmin, a protein that is typically found in muscle cells.
Diagnosis[edit | edit source]
The diagnosis of spindle cell rhabdomyosarcoma is typically made through a combination of imaging studies, biopsy, and histopathological examination. Immunohistochemistry is often used to confirm the diagnosis, with the tumor cells typically expressing desmin and other muscle-specific proteins.
Treatment[edit | edit source]
The treatment of spindle cell rhabdomyosarcoma typically involves a combination of surgery, radiation therapy, and chemotherapy. The specific treatment plan is determined based on the size and location of the tumor, the patient's overall health, and other factors.
Prognosis[edit | edit source]
The prognosis for patients with spindle cell rhabdomyosarcoma is generally poor, with a 5-year survival rate of less than 50%. However, the prognosis can vary widely depending on the size and location of the tumor, the patient's overall health, and other factors.
See also[edit | edit source]
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD