TRPC5

TRPC5 is a protein that in humans is encoded by the TRPC5 gene. It is a member of the transient receptor potential channel (TRPC) group of ion channels. These channels are involved in various types of sensory perception and are known to influence a wide range of biological and physiological processes.

Function[edit | edit source]

TRPC5 is a non-selective cation channel that is activated in response to changes in the cellular environment. It is permeable to calcium ions, which play a crucial role in cellular signaling pathways. The channel is thought to be involved in the regulation of neuronal growth and development, as well as in the modulation of neuronal excitability.

Structure[edit | edit source]

The TRPC5 protein is composed of six transmembrane domains, with a pore region located between the fifth and sixth domains. The N- and C-termini of the protein are located in the cytoplasm. The N-terminus contains ankyrin repeats, which are thought to be involved in protein-protein interactions.

Clinical significance[edit | edit source]

Mutations in the TRPC5 gene have been associated with a number of neurological disorders, including autism, schizophrenia, and bipolar disorder. In addition, overexpression of TRPC5 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.

Research[edit | edit source]

Research into the function and regulation of TRPC5 is ongoing, with a particular focus on its role in neurological disorders and cancer. Understanding the mechanisms by which TRPC5 contributes to these conditions could potentially lead to the development of new therapeutic strategies.

File:TRPC5.png

Structure of the TRPC5 protein.