Tiapamil
Tiapamil is a calcium channel blocker used in the treatment of cardiovascular disease. It is a non-dihydropyridine member of the phenylalkylamine class, similar to verapamil.
Pharmacology[edit | edit source]
Tiapamil acts by inhibiting the influx of calcium ions into cardiac muscle and smooth muscle cells. This inhibition results in the relaxation of these muscles, leading to a decrease in blood pressure and a reduction in heart rate. It also has anti-arrhythmia properties, making it useful in the treatment of conditions such as atrial fibrillation and supraventricular tachycardia.
Clinical Use[edit | edit source]
Tiapamil is used in the management of hypertension, angina pectoris, and certain types of cardiac arrhythmias. It is also used off-label for the prevention of migraine headaches.
Side Effects[edit | edit source]
Common side effects of Tiapamil include dizziness, fatigue, nausea, and constipation. Less common but more serious side effects can include bradycardia, hypotension, and heart block.
Contraindications[edit | edit source]
Tiapamil is contraindicated in patients with severe heart failure, significant bradycardia, and second- or third-degree heart block without a functioning pacemaker.
Drug Interactions[edit | edit source]
Tiapamil can interact with a number of other medications, including beta blockers, digoxin, and statins. These interactions can lead to increased levels of these medications in the body, potentially resulting in toxicity.
See Also[edit | edit source]
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD