Trandolapril/verapamil

Trandolapril/verapamil is a medication combination used in the treatment of hypertension (high blood pressure). It contains two active ingredients: trandolapril, an angiotensin converting enzyme inhibitor, and verapamil, a calcium channel blocker.

Etymology[edit | edit source]

The name "trandolapril" is derived from the chemical structure of the drug, which includes a triazolo ring and a proline moiety. The "verapamil" part of the name is derived from the chemical structure of the drug, which includes a veratrum (a type of plant) alkaloid and an amine group.

Pharmacology[edit | edit source]

Trandolapril works by inhibiting the angiotensin converting enzyme, which is involved in the production of a substance called angiotensin II. Angiotensin II causes blood vessels to constrict and promotes the release of another substance called aldosterone, which increases the amount of sodium and water in the body. By inhibiting the production of angiotensin II, trandolapril helps to relax and widen blood vessels and reduce the amount of water reabsorbed by the kidneys, thereby lowering blood pressure.

Verapamil works by blocking calcium from entering the muscle cells of the heart and arteries. Calcium is needed for these cells to contract, so by blocking its entry, verapamil helps to relax and widen blood vessels, which lowers blood pressure.

Side Effects[edit | edit source]

Common side effects of trandolapril/verapamil include dizziness, headache, cough, and fatigue. Less common side effects include rash, nausea, and abdominal pain. Rare but serious side effects include kidney failure, liver failure, and hypotension (low blood pressure).

Related Terms[edit | edit source]

Trandolapril/verapamil Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.