Fluticasone furoate

Fluticasone_furoate.svg

Fluticasone furoate is a synthetic corticosteroid used to treat various inflammatory and allergic conditions. It is commonly administered as a nasal spray or inhaler for the management of allergic rhinitis and asthma.

Medical Uses

Fluticasone furoate is primarily used for the treatment of:

• Allergic rhinitis: It helps to alleviate symptoms such as nasal congestion, sneezing, and runny nose.
• Asthma: It is used as a maintenance treatment to prevent and control asthma symptoms.

Mechanism of Action

Fluticasone furoate works by binding to glucocorticoid receptors in the body, leading to a reduction in the production of inflammatory mediators such as cytokines and chemokines. This action helps to decrease inflammation and immune responses in the affected tissues.

Pharmacokinetics

Fluticasone furoate has a high affinity for the glucocorticoid receptor, which contributes to its potent anti-inflammatory effects. It is metabolized primarily in the liver by the enzyme CYP3A4 and has a relatively low systemic bioavailability when administered via nasal or inhalation routes.

Side Effects

Common side effects of fluticasone furoate include:

• Nasal irritation
• Headache
• Sore throat
• Cough

Serious side effects, though rare, may include:

• Adrenal suppression
• Osteoporosis
• Glaucoma
• Cataracts

Contraindications

Fluticasone furoate is contraindicated in individuals with:

• Hypersensitivity to fluticasone or any of its components
• Untreated bacterial, viral, or fungal infections in the nasal passages or lungs

Formulations

Fluticasone furoate is available in various formulations, including:

• Nasal spray: Used for the treatment of allergic rhinitis.
• Inhaler: Used for the maintenance treatment of asthma.

Brand Names

Fluticasone furoate is marketed under several brand names, including:

• Veramyst
• Arnuity Ellipta
• Breo Ellipta (in combination with vilanterol)

See Also

• Corticosteroid
• Allergic rhinitis
• Asthma
• Glucocorticoid receptor

External Links

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian