Zyflo Cr

Zyflo CR is a medication used in the management and treatment of chronic asthma. It is a controlled-release formulation of the active ingredient zileuton, which belongs to a class of drugs known as 5-lipoxygenase inhibitors. This medication works by blocking the action of the enzyme 5-lipoxygenase, which in turn inhibits the production of leukotrienes. Leukotrienes are substances in the body that can cause asthma symptoms by inducing inflammation, bronchoconstriction, and mucus production in the airways. By reducing the production of leukotrienes, Zyflo CR helps to control and prevent the symptoms of asthma.

Indications

Zyflo CR is indicated for the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older. It is not intended for the acute treatment of asthma attacks or for status asthmaticus.

Mechanism of Action

Zyflo CR's active ingredient, zileuton, inhibits the enzyme 5-lipoxygenase. This enzyme is crucial in the biosynthesis pathway of leukotrienes, which are inflammatory mediators involved in the pathophysiology of asthma. By inhibiting this enzyme, zileuton reduces the overall production of leukotrienes, thereby decreasing inflammation, bronchoconstriction, and mucus secretion associated with asthma.

Dosage and Administration

Zyflo CR is administered orally, typically twice a day, with or without food. The exact dosage and frequency depend on the patient's condition and response to treatment. It is important for patients to take this medication regularly to get the most benefit from it. Patients should also continue taking other asthma medications as prescribed by their healthcare provider.

Side Effects

Common side effects of Zyflo CR include sinusitis, nausea, and throat pain. Some patients may experience liver enzyme elevations, so regular monitoring of liver function tests is recommended during treatment. Serious side effects are rare but can include severe liver injury. Patients should seek immediate medical attention if they experience symptoms of liver problems, such as persistent nausea, vomiting, abdominal pain, dark urine, or jaundice.

Contraindications

Zyflo CR is contraindicated in patients with known hypersensitivity to zileuton or any component of the formulation. It is also contraindicated in patients with active liver disease or persistent elevations of serum transaminases.

Drug Interactions

Zyflo CR can interact with other medications, potentially affecting their efficacy or increasing the risk of adverse effects. It is particularly important to avoid concomitant use with other medications that can also elevate liver enzymes or those metabolized by the liver. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements.

Conclusion

Zyflo CR is an effective medication for the management of chronic asthma in adults and children over the age of 12. Its mechanism of action, targeting the production of leukotrienes, offers a specific approach to controlling asthma symptoms. However, patients must be monitored for liver function and be aware of potential drug interactions. As with any medication, it is crucial to use Zyflo CR under the guidance of a healthcare provider to ensure its safe and effective use.