File:Phlebotomus pappatasi bloodmeal continue2.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	14:15, 29 July 2008		3,408 × 2,315 (1.78 MB)	Abanima	{{Information \|Description={{en\|1= This photograph depicts a Phlebotomus papatasi sandfly, which had landed atop the skin surface of the photographer, who’d volunteered himself as host for this specimen’s blood meal. The sandflies are members of the D

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Image title	2006 Frank Collins Leishmaniasis is transmitted by the bite of infected female phlebotomine sandflies, injecting the infective stage (i.e., promastigotes) from their proboscis during blood meals. Promastigotes that reach the puncture wound are phagocytized by macrophages ,and other types of mononuclear phagocytic cells, and inside these cells, transform into the tissue stage of the parasite (i.e., amastigotes), which multiply by simple division and proceed to infect other mononuclear phagocytic cells. Parasite, host, and other factors affect whether the infection becomes symptomatic and whether cutaneous or visceral leishmaniasis results. Sandflies become infected by ingesting infected cells during blood meals. In sandflies, amastigotes transform into promastigotes, develop in the gut, (in the hindgut for leishmanial organisms in the <i>Viannia</i> subgenus; in the midgut for organisms in the <i>Leishmania</i> subgenus), and migrate to the proboscis. See PHIL 3400 for a diagram of this cycle.
Author	Photographer: James Gathany
Orientation	Normal
Horizontal resolution	300 dpi
Vertical resolution	300 dpi
Software used	Adobe Photoshop Elements 2.0
File change date and time	14:58, 29 July 2008
Color space	Uncalibrated