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Examples of the feedback loops regulating the P13K-Akt pathway. Akt activation suppresses PTEN via NF-κB, allowing further activation (positive feedback). Akt activation also suppresses P13K via mTOR and IRS-1, preventing further activation (negative feedback).
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Examples of the feedback loops regulating the P13K-Akt pathway. Akt activation suppresses PTEN via NF-κB, allowing further activation (positive feedback). Akt activation also suppresses P13K via mTOR and IRS-1, preventing further activation (negative...