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Antineoplastic agents 0-9
...olated from a renal cell carcinoma cell line that overexpressed FGF-5, FGF-5:117-126 peptide is recognized by tumor infiltrating cytotoxic T lymphocytes ...n of the adrenal androgens dehydroepiandrosterone and androstenedione into 5-androstenediol and testosterone. By blocking testosterone production, ASP95

25 KB (3,415 words) - 01:32, 19 March 2024
Food additive
* [[(+/-)-1-hepten-3-ol]] * [[(+/-)-2-(5-methyl-5-vinyltetrahydrofuran-2-yl)propionaldehyde]]

129 KB (11,984 words) - 20:39, 24 December 2022
List of cancer drugs
* '''Antimetabolites''': [[Methotrexate]] and [[5-Fluorouracil]] (5-FU) * [[3,3'-Diindolylmethane]]

25 KB (1,921 words) - 12:07, 29 March 2024
List of chemotherapeutic agents
...ys, antimetabolites interfere with DNA and RNA synthesis. Methotrexate and 5-fluorouracil are common examples. * [[1,4,6-Androstatriene-3,17-dione]]

26 KB (2,020 words) - 01:50, 15 March 2024
Antineoplastic agents f
...nt F16 (scFv) against the extra-domain A1 of tenascin-C fused, via a short 5-amino acid linker, to a recombinant form of the human cytokine interleukin- ...h cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic st

92 KB (12,847 words) - 01:33, 19 March 2024
Antineoplastic agents d
...ytosol of melanoma cells, may be expressed as the fusion protein D1/3-Mage-3; this fusion protein may boost antitumoral immune responses when used in a ...An orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase (PI3K) and the mammalian target of rapamycin (mTOR), with potential

123 KB (17,062 words) - 01:32, 19 March 2024
Antineoplastic agents a6
...he full-length cancer-testis antigens, CT7 and melanoma-associated antigen 3 (MAGE-A3), and the self-differentiation tumor antigen, Wilms tumor 1 (WT1) ...specific hepatocellular carcinoma (HCC) antigens, including glypican (GPC)-3, New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and alpha-fetopro

134 KB (18,582 words) - 01:36, 19 March 2024
Antineoplastic agents a1
...preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces ...lutamine. Acivicin inhibits glutamine amidotransferases in the purine and pyrimidine biosynthetic pathways, thereby inhibiting tumor growth in cell lines depend

82 KB (11,542 words) - 01:35, 19 March 2024
Antineoplastic agents e
...hospholipid metabolism. Edelfosine also inhibits the phosphatidylinositol 3 kinase (PI3K)-AKT/PKB survival pathway, possibly activating the pro-apoptot ...o the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3-bind

125 KB (17,564 words) - 01:33, 19 March 2024
Antineoplastic agents s
...ll-mediated tumor cell lysis resulting in a reduction in tumor growth. TIM-3, a transmembrane protein expressed on certain T-cells, is associated with t ...g the balance towards pro-apoptotic as opposed to anti-apoptotic isoforms, 3) down-regulation of the anti-apoptotic protein survivin via Wnt signaling.

165 KB (23,057 words) - 01:35, 19 March 2024
Encyclopedia-of-medicine-P1
*[[Pleckstrin homology like domain family b member 3 gene]] *[[Pleckstrin homology-like domain, family b, member 3 gene]]

162 KB (16,323 words) - 04:33, 5 November 2023
Antineoplastic agents b
...ess alphaGal. AlphaGal is not normally expressed in humans because alpha(1,3)-galactosyltransferase (Alpha-GT), the enzyme that catalyzes the synthesis * '''[[Bactobolin]]''' - A 3-dichloromethylactinobolin antineoplastic antibiotic isolated from various P

135 KB (18,952 words) - 01:32, 19 March 2024
Antineoplastic agents l
...mab govitecan selectively binds to carcinoembryonic cell adhesion molecule 5 (CEACAM5), which is abundantly expressed on the surface of a majority of so ...oxydaunorubicin (idarubicin) analog with an aziridinyl group in position C-3' and a methylsulphonyl on position C-4', with potential antineoplastic acti

127 KB (17,614 words) - 01:34, 19 March 2024
Antineoplastic agents t
...factor (EGF), binds to ErbB1 homodimers and heterodimers as well as ErbB2/3 heterodimers, but not to ErbB2 or erbB3 alone. Upon intratumoral administra ...e cellular excision repair pathway for removing DNA replication-inhibiting pyrimidine dimers produced within duplex DNA through exposure to ultraviolet (UV) irra

203 KB (27,948 words) - 01:35, 19 March 2024
Antineoplastic agents c
...FR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (T ...FR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (T

245 KB (34,265 words) - 01:32, 19 March 2024
Antineoplastic agents pq
...ovalently linked to the proprietary 19 amino acid peptide angiopep-2, in a 3:1 ratio, with potential antineoplastic activity. Upon administration, pacli ...covalent inhibitor of human fibroblast growth factor receptor types 1, 2, 3 and 4 (FGFR1-4) with potential antiangiogenic and antineoplastic activities

282 KB (39,590 words) - 01:34, 19 March 2024
Antineoplastic agents r
...oclonal antibody CC49 is developed from the murine monoclonal antibody B72.3 and is humanized by grafting the hypervariable regions onto the variable li ...erived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this age

142 KB (19,609 words) - 01:34, 19 March 2024
Pediatric glossary of terms
* [[17-beta-hydroxysteroid dehydrogenase 3 deficiency]] * [[3-beta-hydroxysteroid dehydrogenase deficiency]]

154 KB (13,094 words) - 04:47, 5 November 2023
Pediatric glossary of terms expanded
* [[17-beta-hydroxysteroid dehydrogenase 3 deficiency]] * [[3-beta-hydroxysteroid dehydrogenase deficiency]]

144 KB (13,060 words) - 11:47, 19 February 2024
Encyclopedia-of-medicine-C
*[[C jun kinase 3]] *[[Cadherin 3 gene]]

220 KB (22,165 words) - 13:19, 29 August 2022