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  • ...ing immune system function. The first anti-cancer drug targeting an immune checkpoint was ipilimumab, a CTLA4 blocker approved in the United States in 2011<br>[[
    587 bytes (79 words) - 00:58, 8 April 2024
  • * [[Immune checkpoint inhibitor]] * [[Immunologic fecal occult blood test]]
    9 KB (766 words) - 10:52, 4 November 2023
  • ...e, potentially augmenting cytotoxic T-cell (CTL) responses and maintaining immunologic memory against tumor cells expressing melanoma-specific antigens. The 6MHP ...he cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.
    25 KB (3,415 words) - 01:32, 19 March 2024
  • * '''[[A2a receptor antagonist eos100850]]''' - An orally bioavailable immune checkpoint inhibitor and antagonist of the adenosine A2A receptor (A2AR; ADORA2A), wit ...on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53 deficient tumor cells more vulnerable to antineoplas
    82 KB (11,542 words) - 01:35, 19 March 2024
  • ...ion of T-lymphocytes, and changes the surface expression of certain immune checkpoint modulators. In addition, as an antioxidant, ubidecarenone protects against .... Upon administration, the UCB-derived CD4+/CD25+ Tregs CK0801 may promote immunologic homeostasis and prevent autoimmunity by suppressing self-reactive T-cells.
    103 KB (14,437 words) - 01:35, 19 March 2024
  • ...ble DNA damage. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression. ...ted mitosis, chromosomal misalignment, chromosomal missegregation, mitotic checkpoint complex destabilization, and increased aneuploidy. This leads to the induct
    125 KB (17,564 words) - 01:33, 19 March 2024
  • * '''[[Checkpoint Kinase 1]]''' * '''[[Checkpoint Kinase 2]]'''
    97 KB (12,845 words) - 03:43, 10 March 2024
  • *[[Immune checkpoint modulator]] *[[Immune checkpoint profile]]
    140 KB (17,060 words) - 13:23, 29 August 2022
  • # [[Immunologic adjuvant]] # [[Checkpoint inhibitor]]
    88 KB (6,680 words) - 19:25, 14 June 2023
  • * [[Immune checkpoint inhibitor]] * [[Immune checkpoint protein]]
    176 KB (14,723 words) - 03:34, 6 November 2023