6-phosphogluconate dehydrogenase
6-Phosphogluconate dehydrogenase (6PGD) is an enzyme that in humans is encoded by the PGD gene. It is a part of the pentose phosphate pathway, which is a metabolic pathway parallel to glycolysis. This enzyme catalyzes the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of nicotinamide adenine dinucleotide phosphate (NADP).
Function[edit | edit source]
6-Phosphogluconate dehydrogenase plays a crucial role in the pentose phosphate pathway, which is a necessary process for nucleotide and amino acid biosynthesis and NADPH production. NADPH is an essential reducing equivalent for the biosynthesis of fatty acids and steroids.
Clinical significance[edit | edit source]
Mutations in the PGD gene are associated with 6-phosphogluconate dehydrogenase deficiency. This is a metabolic disorder that causes various symptoms, including neurological dysfunction and hemolytic anemia.
See also[edit | edit source]
References[edit | edit source]
 | This enzyme-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
