CYTH1
CYTH1 (Cytohesin 1), also known as PSCD1 (Pleckstrin homology, Sec7 and coiled-coil domains 1), is a protein that in humans is encoded by the CYTH1 gene. This protein is a member of the cytohesin family, which is involved in cellular signaling and has been implicated in various aspects of cell biology, including cell adhesion, migration, and proliferation.
Function[edit | edit source]
CYTH1 is a guanine nucleotide exchange factor (GEF) that specifically activates ARF (ADP-ribosylation factor) proteins, which are small GTPases involved in vesicle trafficking and cytoskeletal dynamics. By facilitating the exchange of GDP for GTP on ARF proteins, CYTH1 plays a crucial role in intracellular trafficking and the regulation of cell shape and motility. It is also involved in the signaling pathways that control cell proliferation and differentiation.
The protein contains several domains critical for its function: a Sec7 domain responsible for its GEF activity, a coiled-coil domain that may mediate protein-protein interactions, and a pleckstrin homology (PH) domain that can bind phospholipids and is thought to target CYTH1 to the plasma membrane.
Clinical Significance[edit | edit source]
Alterations in the expression or function of CYTH1 have been associated with various human diseases, including cancer. Overexpression of CYTH1 has been observed in certain types of tumors and is believed to contribute to cancer progression by promoting cell proliferation and survival. Additionally, CYTH1 has been implicated in immune responses and may play a role in inflammatory diseases.
Interactions[edit | edit source]
CYTH1 interacts with several proteins, including ARF family members and possibly other cytohesin family proteins. These interactions are essential for its role in cell signaling and membrane trafficking.
Research[edit | edit source]
Ongoing research is focused on elucidating the detailed mechanisms by which CYTH1 regulates ARF proteins and identifying its role in various cellular processes and diseases. Understanding the function of CYTH1 and its interactions may provide new insights into cell biology and offer potential therapeutic targets for treating diseases associated with its dysregulation.
 | This gene article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
