Cinnarizine/dimenhydrinate

Cinnarizine/dimenhydrinate is a combination medication used primarily for the treatment of vertigo and motion sickness. It contains two active ingredients: cinnarizine and dimenhydrinate, both of which are antihistamines.

Etymology

The term "cinnarizine" is derived from the chemical name of the drug, which is 1-(diphenylmethyl)-4-(3-phenylpropyl)piperazine. The term "dimenhydrinate" is derived from the chemical name of the drug, which is (RS)-2-(diphenylmethoxy)-N,N-dimethylethanamine.

Pharmacology

Cinnarizine is a calcium channel blocker that inhibits the influx of calcium ions into cells, thereby preventing the contraction of smooth muscle cells. This action helps to reduce the symptoms of vertigo and motion sickness.

Dimenhydrinate is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It also has sedative properties, which can help to reduce the symptoms of motion sickness.

Indications

Cinnarizine/dimenhydrinate is indicated for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, vertigo, and Meniere's disease.

Side Effects

Common side effects of cinnarizine/dimenhydrinate include drowsiness, dry mouth, and blurred vision. Less common side effects include constipation, restlessness, and confusion.

Related Terms

• Antihistamine
• Calcium channel blocker
• Vertigo
• Motion sickness
• Meniere's disease

See Also

• Cinnarizine
• Dimenhydrinate

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