Medroxyprogesterone acetate

Medroxyprogesterone Acetate (MPA)

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The molecular structure of Medroxyprogesterone Acetate.

Introduction

Medroxyprogesterone Acetate (MPA) is a synthetic derivative of the female hormone progesterone, classified under the family of medications known as progestins. It plays a crucial role in hormone therapy, serving various purposes such as preventing endometrial cancer, managing menstrual disorders, and functioning as a component of birth control methods.

Medical Uses

MPA is utilized in several therapeutic areas, including:

• Endometrial Cancer Prevention: Reducing the risk of endometrial cancer in postmenopausal women who are receiving estrogen hormone therapy.
• Menstrual Disorders: Treating conditions like abnormal uterine bleeding, amenorrhea, and as part of hormone replacement therapy (HRT).
• Contraception: Used alone or in combination with estrogen in oral contraceptives and in injectable forms like Depo-Provera.

Mechanism of Action

MPA works by mimicking the effects of natural progesterone, which is essential for regulating ovulation and menstrual cycles. In contraception, it prevents ovulation, thickens cervical mucus to hinder sperm penetration, and alters the uterine lining to prevent implantation. As part of HRT, it counteracts the proliferative effects of estrogen on the endometrial lining, reducing the risk of cancer development.

Benefits

• Provides an effective method of birth control.
• Reduces the risk of endometrial hyperplasia and cancer when used with estrogen in postmenopausal women.
• Manages and treats abnormal uterine bleeding and other menstrual disorders.

Potential Side Effects

While beneficial, MPA use can be associated with side effects such as:

• Weight gain
• Headaches
• Mood changes
• Menstrual irregularities
• Decreased bone density with long-term use

Considerations

• The selection of MPA as part of a treatment plan should be based on individual health assessments and discussions between a patient and their healthcare provider.
• Regular monitoring and follow-up appointments are crucial to assess the effectiveness and adjust the treatment as necessary.

See Also

• Progesterone
• Hormone replacement therapy
• Contraceptive injection
• Endometrial cancer

External Links

• National Cancer Institute - Medroxyprogesterone Acetate
• World Health Organization - Family Planning/Contraception

Resources

Latest articles - Medroxyprogesterone acetate

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Medroxyprogesterone acetate for any updates.

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