Tranexamic acid
(Redirected from Cyclonova)
Tranexamic acid, a synthetic derivative of the amino acid lysine, is a potent antifibrinolytic medication. Its primary function is to inhibit the activation of plasminogen to plasmin, effectively stalling the process of fibrinolysis. In comparison to similar agents like aminocaproic acid, tranexamic acid stands out for its longer half-life, increased potency, and reduced toxicity.
Mechanism of Action[edit | edit source]
The key to tranexamic acid's function is its high affinity for the five lysine-binding sites of plasminogen. By competitively binding to these sites, tranexamic acid inhibits the conversion of plasminogen to plasmin. Plasmin is an enzyme that is instrumental in the breakdown of fibrin, a protein that forms a mesh-like structure to hold blood clots together. Therefore, by inhibiting plasmin formation, tranexamic acid effectively hinders the process of fibrinolysis, or clot breakdown. At higher concentrations, it can also inhibit plasmin noncompetitively.
Clinical Applications[edit | edit source]
Tranexamic acid is used widely in the management of bleeding conditions. This includes use in surgeries, trauma, heavy menstruation, and bleeding disorders such as hemophilia. It's also used to prevent and treat bleeding in people with blood clotting disorders and those who have had brain surgery.
Safety and Side Effects[edit | edit source]
Tranexamic acid is generally considered safe but, as with all medications, can present side effects. Common side effects may include nausea, vomiting, diarrhea, and mild visual disturbances. Rare but serious side effects can include blood clots, stroke, and impaired color vision.
Pharmacokinetics[edit | edit source]
The advantage of tranexamic acid over similar drugs like aminocaproic acid is its superior pharmacokinetic profile. It has a longer half-life, allowing for less frequent dosing, and it is approximately ten times more potent.
References[edit | edit source]
- Mechanism of action of tranexamic acid
- Clinical applications of tranexamic acid
- Pharmacokinetics and safety profile of tranexamic acid
| Tranexamic acid Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
