Dacuronium bromide

Dacuronium Bromide is a non-depolarizing neuromuscular-blocking drug or neuromuscular-blocking agent and is used in modern anaesthesia at the stage of surgeries to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is a part of the aminosteroid group of neuromuscular-blocking drugs and is generally used in the form of Dacuronium Bromide salts.

Pharmacology

Dacuronium Bromide acts by competing for the cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium. Dacuronium Bromide has a moderately rapid onset, and its lack of significant cardiovascular side effects and its lack of histamine release, have made it popular for use in patients with cardiovascular compromise.

Clinical Use

Dacuronium Bromide is often used for providing muscle relaxation for intubation, which is the insertion of a flexible plastic tube into the trachea to maintain an open airway or to serve as a conduit through which to administer certain drugs. It is also used for muscle relaxation during surgery, particularly during procedures that require the patient to be under general anesthesia.

Side Effects

Like all neuromuscular-blocking agents, Dacuronium Bromide can cause a range of side effects. These can include hypotension, tachycardia, and bronchospasm. In rare cases, it can cause anaphylaxis, a severe and potentially life-threatening allergic reaction.

See Also

• Neuromuscular-blocking drug
• Anaesthesia
• Endotracheal intubation
• Acetylcholinesterase inhibitors