Dacuronium bromide
Dacuronium Bromide is a non-depolarizing neuromuscular-blocking drug or neuromuscular-blocking agent and is used in modern anaesthesia at the stage of surgeries to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is a part of the aminosteroid group of neuromuscular-blocking drugs and is generally used in the form of Dacuronium Bromide salts.
Pharmacology[edit | edit source]
Dacuronium Bromide acts by competing for the cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium. Dacuronium Bromide has a moderately rapid onset, and its lack of significant cardiovascular side effects and its lack of histamine release, have made it popular for use in patients with cardiovascular compromise.
Clinical Use[edit | edit source]
Dacuronium Bromide is often used for providing muscle relaxation for intubation, which is the insertion of a flexible plastic tube into the trachea to maintain an open airway or to serve as a conduit through which to administer certain drugs. It is also used for muscle relaxation during surgery, particularly during procedures that require the patient to be under general anesthesia.
Side Effects[edit | edit source]
Like all neuromuscular-blocking agents, Dacuronium Bromide can cause a range of side effects. These can include hypotension, tachycardia, and bronchospasm. In rare cases, it can cause anaphylaxis, a severe and potentially life-threatening allergic reaction.
See Also[edit | edit source]
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