Holmes–Gang syndrome
Holmes–Gang syndrome is a rare genetic disorder characterized by a variety of physical and neurological abnormalities. The syndrome was first described by Dr. Robert Holmes and Dr. John Gang in the late 20th century.
Symptoms and Signs[edit | edit source]
The symptoms of Holmes–Gang syndrome can vary greatly among affected individuals. Common symptoms include intellectual disability, seizures, microcephaly (small head size), and distinctive facial features such as a prominent forehead, deep-set eyes, and a small jaw. Some individuals may also have hearing loss, vision problems, and abnormalities of the heart, kidneys, or other organs.
Causes[edit | edit source]
Holmes–Gang syndrome is caused by mutations in a specific gene. This gene provides instructions for making a protein that is important for normal brain development. When this gene is mutated, the protein it produces is faulty or absent, leading to the symptoms of the syndrome.
Diagnosis[edit | edit source]
Diagnosis of Holmes–Gang syndrome is based on the presence of characteristic clinical features. Genetic testing can confirm the diagnosis by identifying a mutation in the specific gene associated with the syndrome.
Treatment[edit | edit source]
There is currently no cure for Holmes–Gang syndrome. Treatment is symptomatic and supportive, and may include physical therapy, speech therapy, and occupational therapy to help improve motor skills and communication abilities. Medications may be used to manage seizures and other symptoms.
Prognosis[edit | edit source]
The prognosis for individuals with Holmes–Gang syndrome varies depending on the severity of symptoms. Some individuals may have a normal lifespan with appropriate management of their symptoms, while others may have a shortened lifespan due to complications such as severe seizures or organ abnormalities.
See Also[edit | edit source]
NIH genetic and rare disease info[edit source]
Holmes–Gang syndrome is a rare disease.
| Holmes–Gang syndrome Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
