ORG-21465

ORG-21465 is a sedative drug that was developed by Organon International in the 1990s. It is a steroid derivative, specifically a neuroactive steroid, which has anxiolytic and anticonvulsant effects.

History

ORG-21465 was first synthesized by Organon International, a global pharmaceutical company based in the Netherlands. The company was known for its innovative research and development in the field of pharmaceuticals. ORG-21465 was one of the many drugs developed by the company during its active years.

Pharmacology

ORG-21465 is a neuroactive steroid, a group of steroids that have effects on the nervous system. It acts as a positive allosteric modulator at the GABA_A receptor, the major inhibitory neurotransmitter receptor in the brain. This action enhances the inhibitory effects of GABA, leading to the sedative and anxiolytic effects of the drug.

Clinical Use

The primary use of ORG-21465 is as a sedative for the induction of anesthesia in surgical procedures. It has a rapid onset of action and a short duration of effect, making it suitable for this purpose. It is also used for the treatment of anxiety disorders due to its anxiolytic effects.

Side Effects

Like other sedative drugs, ORG-21465 can cause a range of side effects. These can include drowsiness, confusion, and impaired motor coordination. In rare cases, it can cause more serious effects such as respiratory depression and dependence.

See Also

• Organon International
• Neuroactive steroid
• GABA_A receptor
• Anesthesia
• Anxiety disorders