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N-sulfoglucosamine-3-sulfatase
...dase''') is an [[enzyme]] that is involved in the degradation of [[heparan sulfate]] in [[lysosome]]s. This enzyme is encoded by the SGSH gene in humans. Defi ...s, with N-sulfoglucosamine-3-sulfatase acting at a specific step to remove sulfate groups.

2 KB (228 words) - 06:39, 11 March 2024
Sulfotransferase
...fotransferase]] is a type of [[enzyme]] that catalyzes the transfer of a [[sulfate]] group from a donor molecule to an acceptor molecule. This process, known ...inding domain. The catalytic domain is responsible for the transfer of the sulfate group, while the binding domain recognizes and binds to the acceptor molecu

3 KB (346 words) - 05:11, 11 March 2024
Syndecan-3
...e ''SDC3'' gene. As a member of the syndecan proteoglycan family, Syndecan-3 plays a crucial role in cell proliferation, cell migration, and cell-matrix ...ocated on the cell surface. It consists of a core protein to which heparan sulfate glycosaminoglycan chains are attached. The core protein has a large extrace

3 KB (353 words) - 12:53, 22 March 2024
Glypican
'''Glypican''' is a family of [[heparan sulfate]] [[proteoglycan]]s that are attached to the cell surface via a [[Glycosylp ...okines. They interact with these signaling molecules through their heparan sulfate chains, affecting the ligand-receptor interactions necessary for signal tra

3 KB (368 words) - 09:34, 19 March 2024
Syndecan
...ily]], which includes four known members: Syndecan-1, Syndecan-2, Syndecan-3, and Syndecan-4. These proteins play a crucial role in [[cell adhesion]], [ ...xtracellular domain and can be either [[heparan sulfate]] or [[chondroitin sulfate]].

2 KB (234 words) - 22:33, 25 February 2024
Glypican 3
...phosphatidylinositol|glycosylphosphatidylinositol]] (GPI) anchor. Glypican 3 plays a significant role in [[cell growth]], [[cell differentiation]], and Glypican 3 is primarily expressed in the [[liver]], [[kidney]], and [[lung]], and is i

3 KB (443 words) - 03:59, 30 March 2024
Hereditary multiple osteochondromas
...exostosin-1 and exostosin-2 complex''' modifies a protein called [[heparan sulfate]] so it can be used by the cell'''. ...te cannot be processed correctly and is nonfunctional'''. Although heparan sulfate is involved in many bodily processes, it is unclear how the lack of this pr

8 KB (1,119 words) - 13:06, 27 December 2020
Laronidase
...sis of terminal α-L-iduronic acid residues of dermatan sulfate and heparan sulfate. ...ts in the accumulation of the GAG substrates, dermatan sulfate and heparan sulfate, throughout the body and leads to widespread cellular, tissue, and organ dy

8 KB (1,079 words) - 12:32, 6 October 2022
Scheie syndrome
| image = Dermatan sulfate.PNG | caption = Structure of dermatan sulfate, one of the molecules that accumulates in the lysosomes of Hurler syndrome

7 KB (923 words) - 14:34, 19 April 2021
Hurler syndrome
| image = Dermatan sulfate.PNG | caption = Structure of dermatan sulfate, one of the molecules that accumulates in the lysosomes of Hurler syndrome

15 KB (2,105 words) - 16:09, 1 May 2020
Sanfilippo syndrome
...y of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain}} ...e involved in the step-wise breakdown of a subset of GAGs called [[heparan sulfate]].

21 KB (2,842 words) - 01:00, 12 January 2024
Herpes simplex encephalitis
...an herpes viruses (HHV), including HSV-2, varicella zoster virus (VZV; HHV-3), Epstein–Barr virus (HHV-4), cytomegalovirus (HHV-5), HHV-6, HHV-7, and ...ns]] via interactions with cell-surface glycosaminoglycans such as heparan sulfate , and cell adhesion molecules such as [[nectin-1]] , and travels to the neu

6 KB (828 words) - 12:09, 28 May 2021
Pick's disease
...dy of an autopsied case | journal = Neuropathology | volume = 26 | issue = 3 | pages = 222–230 | year = 2006 | pmid = 16771179| doi = 10.1111/j.1440- ...]], [[Serum amyloid P component|amyloid P]], and [[heparan sulfate|heparan sulfate glycosaminoglycan]].<ref name = Munoz/>

20 KB (2,662 words) - 19:39, 5 March 2024
List of rare diseases-H
* '''[[Hemi 3 syndrome]]''' * '''[[Hemiplegic migraine, familial type 3]]'''

57 KB (7,147 words) - 03:26, 10 April 2022
Implantation (human embryo)
...|publisher=[[Elsevier]] |location=[[Oxford]] |year=2004 |isbn=1-4160-2328-3 |oclc=61527528}}{{Page needed|date=September 2010}}</ref> These cells are c | [[heparan sulfate]]

22 KB (3,130 words) - 07:16, 23 February 2024
MeSH H
* '''[[Hemicholinium 3]]''' * '''[[Heparan Sulfate Proteoglycans]]'''

48 KB (6,234 words) - 03:44, 10 March 2024
Antineoplastic agents a4
...one directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) fused to one that is directed against the CD3 antigen found on T-lym ...cted to the ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3), conjugated via a non-cleavable linker to monomethyl auristatin F (

240 KB (33,186 words) - 01:36, 19 March 2024
Antineoplastic agents h
...ation profile of the histone H3 variant H3.3 at Lys 27. Modification of H3.3 at Lys 27 regulates gene expression, and the H3.3K27M mutation occurs in a ...ng of plasmids encoding the hepatitis C virus (HCV) nonstructural proteins 3 (NS3), 4A (NS4A), 4B (NS4B) and 5A (NS5A), with potential immunomodulating

105 KB (14,813 words) - 01:33, 19 March 2024
Antineoplastic agents uvw
...ytokines that includes stem cell factor (SCF), fms-related tyrosine kinase 3 ligand (Flt3-L), interleukin-15 (IL-15) and insulin-like growth factor-1 (I ...delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. PI3K-delta inhibito

103 KB (14,437 words) - 01:35, 19 March 2024
డిక్షనరీ ఆఫ్ డ్రగ్స్:H
...3 యొక్క మిథైలేషన్ మరియు ఎసిటైలేషన్ ప్రొఫైల్‌ను మారుస్తుంది. Lys 27 వద్ద H3.3 యొక్క మార్పు జన్యు వ్యక్తీక ...ియం చేసే ఫేజ్ సిపిజి మూలాంశాన్ని సూచించే DNA శకలాలు కలిగి ఉంది. HAAH-1 / 2/3 లాంబ్డా ఫేజ్ వ్యాక్సిన్ పాన

320 KB (3,878 words) - 23:08, 6 July 2019