Stathmin

Stathmin or oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene. Stathmin is a ubiquitous intracellular protein that regulates rapid microtubule destabilization and is a relay integrating diverse intracellular signals.

Function

Stathmin is a ubiquitous, cytosolic phosphoprotein that plays a critical role in regulating rapid microtubule remodeling of the cytoskeleton in response to the cell's needs. This remodeling is essential for various biological processes such as intracellular transport, cell morphology, cell migration, and cell division.

Clinical significance

Stathmin is overexpressed in a wide variety of cancers and is a potential target for chemotherapy. It is also a marker for differentiating neuronal tumors and neuroendocrine tumors.

See also

• Microtubule
• Gene
• Protein
• Neuronal tumor
• Neuroendocrine tumor

External links

• STMN1 at the National Center for Biotechnology Information

Stathmin Resources
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