Tilarginine acetate

Tilarginine Acetate is a non-selective inhibitor of nitric oxide synthase. It is used in medical research to understand the role of nitric oxide in various biological processes and diseases.

Chemistry

Tilarginine Acetate, also known as N(G)-monomethyl-L-arginine acetate, is a derivative of the amino acid arginine. It is a white crystalline powder that is soluble in water. The chemical formula of Tilarginine Acetate is C7H16N4O2.C2H4O2.

Mechanism of Action

Tilarginine Acetate inhibits the production of nitric oxide by blocking the action of nitric oxide synthase, an enzyme that catalyzes the production of nitric oxide from arginine. Nitric oxide is a signaling molecule that plays a crucial role in various physiological processes, including vasodilation, neurotransmission, and immune response.

Medical Research

Tilarginine Acetate has been used in medical research to study the role of nitric oxide in various diseases. For example, it has been used to investigate the role of nitric oxide in the pathogenesis of septic shock, a life-threatening condition caused by an overwhelming immune response to infection. In addition, Tilarginine Acetate has been used to study the role of nitric oxide in cardiovascular diseases, such as hypertension and heart failure.

Safety and Side Effects

As with any drug, the use of Tilarginine Acetate can lead to side effects. These can include hypotension, bradycardia, and gastrointestinal disturbances. However, these side effects are generally mild and transient.

See Also

• Nitric Oxide
• Nitric Oxide Synthase
• Arginine
• Septic Shock
• Cardiovascular Diseases