3',4'-Methylenedioxy-α-pyrrolidinopropiophenone

3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (also known as MDPPP) is a designer drug and stimulant of the amphetamine class. It is chemically similar to other substances such as MDPV and pyrovalerone, and is known for its psychoactive effects.

Chemistry[edit | edit source]

MDPPP is a substituted cathinone, which is a type of synthetic cathinone. Synthetic cathinones are derivatives of the naturally occurring substance cathinone, which is a type of amphetamine. MDPPP is structurally related to MDPV and pyrovalerone, and is part of the larger family of phenethylamines.

The chemical formula of MDPPP is C16H23NO3, and its full systematic name is 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-pentanone. The compound features a phenyl ring substituted at R3 and R4 with methylenedioxy bridge. This bridge forms a cyclic structure that is essential for its psychoactive effects.

Pharmacology[edit | edit source]

MDPPP acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), meaning it increases the levels of the neurotransmitters norepinephrine and dopamine in the brain by inhibiting their reuptake into neurons. This results in increased neuronal activity and stimulation.

The exact mechanism of action of MDPPP is not fully understood, but it is believed to involve the inhibition of monoamine transporters, leading to an increase in the concentration of dopamine, norepinephrine, and serotonin in the brain.

Effects[edit | edit source]

The effects of MDPPP can vary greatly depending on the dose, the individual's physiology, and the method of administration. Common effects reported by users include feelings of euphoria, increased alertness and energy, enhanced mood, and increased sociability.

However, MDPPP also has a number of potential adverse effects, including tachycardia, hypertension, vasoconstriction, and potential for addiction and dependence. Long-term use can lead to severe psychological effects, including anxiety, paranoia, and psychosis.

Legal Status[edit | edit source]

The legal status of MDPPP varies by country. In many countries, including the United States, it is classified as a controlled substance due to its potential for abuse and addiction.

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