Pamidronic acid
(Redirected from Amidronate)
Pamidronic acid (also known as pamidronate) is a bisphosphonate that is used to prevent bone loss. It is marketed under the brand name Aredia among others.
Etymology[edit | edit source]
The term "pamidronic acid" is derived from the chemical name 3-amino-1-hydroxypropylidene-1,1-bisphosphonic acid. The prefix "pamidron-" is a reference to the presence of the amino group in the molecule, while "-ic acid" indicates that it is an acid.
Medical Uses[edit | edit source]
Pamidronic acid is used to treat a variety of conditions that affect the bone. These include osteoporosis, Paget's disease, and hypercalcemia associated with malignancy. It is also used to prevent bone loss in patients undergoing certain types of cancer treatment.
Mechanism of Action[edit | edit source]
Pamidronic acid works by binding to hydroxyapatite in bone tissue, preventing the breakdown of bones by osteoclasts. This helps to maintain bone density and strength.
Side Effects[edit | edit source]
Common side effects of pamidronic acid include nausea, vomiting, fever, and bone pain. In rare cases, it can cause serious side effects such as osteonecrosis of the jaw and atrial fibrillation.
Related Terms[edit | edit source]
- Bisphosphonate
- Osteoporosis
- Paget's disease
- Hypercalcemia
- Cancer
- Hydroxyapatite
- Osteoclast
- Nausea
- Vomiting
- Fever
- Bone pain
- Osteonecrosis
- Atrial fibrillation
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Contributors: Prab R. Tumpati, MD
