Azlocillin

From WikiMD's Wellness Encyclopedia

(Redirected from Azlin)

Azlocillin synthesis
Azlocillin synthesis2

Azlocillin is an antibiotic belonging to the class of penicillins. It is a semi-synthetic compound that was developed to treat infections caused by Pseudomonas aeruginosa and other Gram-negative bacteria. Azlocillin works by inhibiting the synthesis of the bacterial cell wall, leading to the death of the bacteria. This mechanism is similar to other penicillins but azlocillin has been specifically optimized for activity against certain resistant strains of bacteria.

Medical Uses[edit | edit source]

Azlocillin is primarily used in the treatment of infections caused by Pseudomonas aeruginosa, a pathogen known for its resistance to many antibiotics and its association with hospital-acquired infections. These infections can include pneumonia, urinary tract infections (UTIs), septicemia, and infections in patients with cystic fibrosis. Due to its broad spectrum of activity, azlocillin may also be effective against infections caused by other Gram-negative organisms as well as some Gram-positive bacteria.

Pharmacology[edit | edit source]

The pharmacological action of azlocillin involves the inhibition of bacterial cell wall synthesis, a common mechanism among penicillin antibiotics. By binding to and inactivating specific penicillin-binding proteins (PBPs) on the bacterial cell wall, azlocillin prevents the cross-linking of peptidoglycan chains necessary for cell wall strength and rigidity. This action leads to cell lysis and the eventual death of the bacterium.

Azlocillin is administered intravenously, as its bioavailability is poor when taken by mouth. It is distributed widely in the body, including in the pleural fluid, ascites, and cerebrospinal fluid (CSF), making it useful in treating infections in various body sites.

Side Effects[edit | edit source]

Like other penicillins, azlocillin can cause a range of side effects. The most common include allergic reactions, which can range from mild rashes to severe anaphylaxis. Gastrointestinal disturbances such as nausea, vomiting, and diarrhea are also common. Less frequently, patients may experience changes in blood counts, including neutropenia and thrombocytopenia, or liver enzyme elevations.

Resistance[edit | edit source]

The emergence of bacterial resistance to azlocillin, as with other antibiotics, is a significant concern. Resistance mechanisms include the production of beta-lactamases that hydrolyze the antibiotic, alterations in the target PBPs, and changes in membrane permeability that reduce drug uptake. The use of azlocillin, like all antibiotics, should be guided by susceptibility testing to ensure effectiveness against the infecting organism and to help limit the development of resistance.

Conclusion[edit | edit source]

Azlocillin is an important antibiotic in the treatment of infections caused by Pseudomonas aeruginosa and other resistant Gram-negative bacteria. Its role in combating hospital-acquired infections and infections in immunocompromised patients is particularly valuable. However, the emergence of resistance highlights the need for judicious use and ongoing research into new antimicrobial agents.


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD