PTI-3
PTI-3 is a chemical compound that is used as a pharmacological tool in the study of the Sigma-1 receptor. It is one of the most selective Sigma-1 receptor ligands currently available, and has been used to demonstrate that the Sigma-1 receptor mediates the neuroprotective effects of pregnenolone and DHEA.
Chemistry[edit | edit source]
PTI-3 is a benzomorphan derivative, and is structurally related to the opioid antagonist naloxone. However, unlike naloxone, PTI-3 does not have significant affinity for opioid receptors, and instead binds selectively to the Sigma-1 receptor.
Pharmacology[edit | edit source]
PTI-3 acts as an agonist at the Sigma-1 receptor, and has been shown to produce neuroprotective effects in animal models of neurodegenerative disease. These effects are thought to be mediated by the Sigma-1 receptor, as they can be blocked by the selective Sigma-1 receptor antagonist BD-1063.
Research[edit | edit source]
Research into the potential therapeutic applications of PTI-3 is ongoing. It has been suggested that Sigma-1 receptor agonists like PTI-3 may have potential in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as in the treatment of depression and anxiety disorders.
See also[edit | edit source]
References[edit | edit source]
| PTI-3 Resources | ||
|---|---|---|
|
| |
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Contributors: Prab R. Tumpati, MD
