Samarium Sm 153 lexidronam pentasodium

From WikiMD's Wellness Encyclopedia

A radiopharmaceutical used in the treatment of bone pain associated with cancer metastases


CaptionSynonyms
Samarium Sm 153 lexidronam pentasodium
Drug Information
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Identifiers




ChEBI


Chemical Data

C H N O Molecular Weight



Samarium Sm 153 lexidronam pentasodium, also known by the brand name Quadramet, is a radiopharmaceutical used primarily for the relief of bone pain in patients with bone metastases from cancer. It is a complex of the radioactive isotope samarium-153 and ethylenediaminetetramethylenephosphonic acid (EDTMP), which targets areas of increased bone turnover.

Mechanism of Action[edit | edit source]

Samarium Sm 153 lexidronam pentasodium works by delivering targeted radiation to bone metastases. The samarium-153 isotope emits beta particles, which have a therapeutic effect by damaging the DNA of nearby cancer cells, leading to cell death. The EDTMP component of the drug acts as a chelating agent, binding to the samarium and directing it to areas of high bone turnover, such as those affected by metastatic cancer.

Indications[edit | edit source]

Samarium Sm 153 lexidronam pentasodium is indicated for the treatment of bone pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on bone scan. It is commonly used in patients with metastatic prostate cancer and breast cancer.

Administration[edit | edit source]

The drug is administered intravenously, typically as a single dose. The dosage is calculated based on the patient's body weight and the specific activity of the samarium-153 isotope. Following administration, patients are monitored for potential side effects and radiation exposure.

Side Effects[edit | edit source]

Common side effects of Samarium Sm 153 lexidronam pentasodium include:

  • Hematological effects such as thrombocytopenia and leukopenia
  • Nausea
  • Vomiting
  • Diarrhea
  • Injection site reactions

Patients receiving this treatment should be monitored for bone marrow suppression and other potential adverse effects.

Safety and Precautions[edit | edit source]

Due to its radioactive nature, Samarium Sm 153 lexidronam pentasodium should be handled with care. Healthcare providers must follow appropriate safety protocols to minimize radiation exposure to themselves and others. The drug is contraindicated in pregnant women due to the potential risk to the fetus.

Also see[edit | edit source]




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Contributors: Prab R. Tumpati, MD