Serum glutamic oxaloacetic transaminase
| Serum glutamic oxaloacetic transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.1 | ||||||||
| CAS number | 9000-97-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Serum glutamic oxaloacetic transaminase (SGOT), also known as aspartate aminotransferase (AST), is an enzyme that is typically found in the liver, heart, kidney, pancreas, and muscles. It plays a crucial role in amino acid metabolism, specifically in the transamination process where it catalyzes the conversion of aspartate and alpha-ketoglutarate into glutamate and oxaloacetate.
Function[edit | edit source]
SGOT is involved in the urea cycle and the Krebs cycle, which are essential for removing ammonia from the body and for energy production, respectively. The enzyme's activity is vital for the synthesis and breakdown of amino acids and for the production of glucose and energy during cellular respiration.
Clinical significance[edit | edit source]
Elevated levels of SGOT can be an indicator of liver damage or disease, such as hepatitis or cirrhosis. It is also elevated in conditions involving muscle damage, including myocardial infarction (heart attack) and muscular dystrophy. SGOT is commonly measured in a blood test along with alanine transaminase (ALT) to assess liver health.
Diagnostic use[edit | edit source]
The SGOT test is part of the liver function tests and helps in diagnosing liver diseases. It is also used to monitor the treatment of patients with liver disease, to detect liver damage due to drugs, and to differentiate between liver and heart diseases.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
