Oxaloacetate

Oxaloacetate is a four-carbon molecule found in the mitochondria that combines with Acetyl-CoA and water to form Citrate in the first step of the Citric Acid Cycle. It is also involved in Gluconeogenesis, the Urea Cycle, the Glyoxylate Cycle, and the synthesis of Amino Acids.

Structure and properties

Oxaloacetate is a carboxylic acid. It is colorless, and it exists as a solid and soluble in water. Its chemical formula is C4H4O5. Its systematic name is Oxobutanedioic acid.

Biochemical role

Oxaloacetate plays a crucial role in various metabolic processes, including:

• Citric Acid Cycle: Oxaloacetate is a key component in the citric acid cycle. It combines with Acetyl-CoA to form citrate, catalyzed by the enzyme Citrate Synthase.
• Gluconeogenesis: In animals, oxaloacetate is a source of glucose synthesis.
• Amino Acid synthesis: Oxaloacetate is converted to aspartate, a precursor to several amino acids.
• Urea Cycle: Oxaloacetate is a participant in the urea cycle where it is transformed to aspartate.

Health implications

Oxaloacetate has been studied for its potential health benefits. Some research suggests that it may extend lifespan, improve brain health, and help with weight loss. However, more research is needed to confirm these potential benefits.

See also

• Citric Acid Cycle
• Gluconeogenesis
• Amino Acid
• Urea Cycle

Oxaloacetate Resources
Most recent articles Ongoing trials	Wikipedia

References

External links

• Oxaloacetic acid at PubChem
• Oxaloacetate at NCBI Bookshelf

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