Sodium phenylbutyrate/ursodoxicoltaurine

Sodium phenylbutyrate/ursodoxicoltaurine is a combination drug used in the treatment of various medical conditions. It is a combination of two active ingredients: sodium phenylbutyrate and ursodoxicoltaurine.

Sodium phenylbutyrate

Sodium phenylbutyrate is a medication used for the treatment of urea cycle disorders, rare genetic disorders that result in a deficiency of one of the six enzymes in the urea cycle. These disorders often lead to an accumulation of ammonia in the blood, which can cause serious health problems. Sodium phenylbutyrate works by providing an alternative pathway to excrete nitrogen from the body, thus reducing the levels of ammonia.

Ursodoxicoltaurine

Ursodoxicoltaurine, also known as ursodeoxycholic acid or UDCA, is a secondary bile acid, which is produced in the liver and is important for the digestion and absorption of fats and vitamins in the intestines. It is used in the treatment of gallstones and liver diseases. In the context of the combination drug with sodium phenylbutyrate, it is believed to enhance the effects of the latter.

Combination Drug

The combination of sodium phenylbutyrate and ursodoxicoltaurine is used in the treatment of primary biliary cirrhosis, a chronic disease of the liver. The combination drug works by reducing the production of harmful substances in the liver and improving the flow of bile. It also helps to reduce the symptoms of the disease, such as itching and fatigue.

Side Effects

Like all medications, sodium phenylbutyrate/ursodoxicoltaurine can cause side effects. Common side effects include nausea, vomiting, and abdominal pain. Less common side effects can include changes in liver function tests, hair thinning, and rash. It is important to monitor for these side effects and to seek medical attention if they occur.

Dosage

The dosage of sodium phenylbutyrate/ursodoxicoltaurine will depend on the individual patient's condition and response to treatment. It is important to take this medication exactly as prescribed by a healthcare provider.

See Also

• Urea cycle disorders
• Primary biliary cirrhosis
• Liver disease
• Bile acid

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