Μ-Opioid receptor

Μ-Opioid receptor (MOR) is a type of opioid receptor with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. It is considered the principal receptor target of the opioid drug morphine.

Structure

The Μ-Opioid receptor is a G protein-coupled receptor (GPCR) that responds to the endogenous opioid peptides beta-endorphin, enkephalin, and endorphin. It is encoded by the OPRM1 gene.

Function

The Μ-Opioid receptor plays a key role in mediating the effects of opioids and opioid-like substances. These effects include analgesia, euphoria, respiratory depression, and constipation. The receptor is also involved in reward systems and the development of opioid addiction.

Pharmacology

The Μ-Opioid receptor is the primary target of most opioid analgesics, including morphine, heroin, and fentanyl. These drugs bind to the receptor and activate it, leading to their analgesic and euphoric effects. However, prolonged use of these drugs can lead to tolerance and physical dependence, as well as the risk of overdose.

Clinical significance

The Μ-Opioid receptor is a major target in the treatment of pain, and drugs that act on this receptor are used in a wide range of clinical settings. However, the use of these drugs is associated with significant risks, including the development of addiction and the risk of overdose. Research is ongoing to develop safer opioid analgesics that can provide effective pain relief without these risks.

See also

• Delta opioid receptor
• Kappa opioid receptor
• Opioid receptor

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