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Dichloropane (RTI-111, RTI-31) is a stimulant of the phenyltropane class that acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with Ki values of 4.36 nM, 20.4 nM, and 37.4 nM, respectively. It is around 5 times more potent than cocaine at blocking dopamine reuptake, but is relatively unselective.

Etymology[edit | edit source]

The name "Dichloropane" is derived from its chemical structure, which consists of a tropane ring with two chlorine atoms attached (di- meaning "two" and chloro- referring to chlorine).

Pharmacology[edit | edit source]

Dichloropane is a potent stimulant that acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It has a high affinity for the dopamine transporter (DAT), the norepinephrine transporter (NET), and the serotonin transporter (SERT). This results in an increase in the concentration of these neurotransmitters in the synaptic cleft, leading to increased neurotransmission.

Chemistry[edit | edit source]

Dichloropane is a member of the phenyltropane class of compounds, which are known for their high potency as dopamine reuptake inhibitors. It is structurally similar to cocaine, but differs in that it has two chlorine atoms attached to the tropane ring.

Legality[edit | edit source]

Dichloropane is a Schedule I controlled substance in the United States, meaning it has a high potential for abuse and no accepted medical use.

See also[edit | edit source]

References[edit | edit source]

Dichloropane Resources

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Contributors: Prab R. Tumpati, MD