4'-Dimethylamino-7,8-dihydroxyflavone

4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF) is a synthetic derivative of the naturally occurring flavonoid 7,8-dihydroxyflavone. It is a potent and selective agonist of the TrkB receptor, which is a part of the neurotrophin receptor family.

Chemistry

4'-DMA-7,8-DHF is a flavonoid, a class of polyphenolic compounds that are widely distributed in the plant kingdom. The compound is characterized by the presence of a dimethylamino group at the 4' position of the flavone backbone. The 7,8-dihydroxy groups are responsible for its activity as a TrkB agonist.

Pharmacology

4'-DMA-7,8-DHF acts as a potent and selective agonist of the TrkB receptor, a receptor for the neurotrophin brain-derived neurotrophic factor (BDNF). It has been shown to mimic the neuroprotective effects of BDNF in vitro and in vivo. The compound has been investigated for potential therapeutic applications in neurodegenerative diseases and psychiatric disorders.

Therapeutic Potential

Research has suggested that 4'-DMA-7,8-DHF may have potential therapeutic applications in a variety of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, depression, and anxiety disorders. These disorders are associated with reduced BDNF signaling, and 4'-DMA-7,8-DHF, as a TrkB agonist, could potentially enhance BDNF signaling and alleviate symptoms.

Safety and Toxicity

The safety and toxicity of 4'-DMA-7,8-DHF have not been fully established. As with any new therapeutic compound, further research is needed to determine its safety profile.

See Also

• Flavonoid
• 7,8-dihydroxyflavone
• TrkB receptor
• Neurotrophin
• Brain-derived neurotrophic factor

4'-Dimethylamino-7,8-dihydroxyflavone Resources
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