Abafungin

Abafungin is a broad-spectrum antifungal agent with a novel mode of action and potent activity against key pathogenic fungi, including Candida, Aspergillus, and Dermatophytes. It is a non-azole, non-polyene antifungal agent that inhibits the synthesis of ergosterol, a key component of the fungal cell membrane.

Etymology

The term "Abafungin" is derived from the chemical structure of the compound. The prefix "aba-" is derived from the Latin word "ab", meaning "from", and "fungin" is derived from the Latin word "fungus", meaning "fungus". Thus, "Abafungin" can be translated as "from fungus".

Mechanism of Action

Abafungin inhibits the synthesis of ergosterol by inhibiting the enzyme squalene epoxidase. This results in a disruption of the fungal cell membrane and ultimately leads to the death of the fungal cell. Unlike other antifungal agents, Abafungin does not require conversion into an active metabolite and is active in its original form.

Clinical Use

Abafungin has been shown to be effective in the treatment of various fungal infections, including Candidiasis, Aspergillosis, and Dermatophytosis. It is available in a topical formulation for the treatment of skin and nail infections.

Side Effects

The most common side effects of Abafungin are local reactions at the site of application, such as burning, itching, and redness. Systemic side effects are rare but can include nausea, vomiting, and diarrhea.

Related Terms

• Antifungal
• Ergosterol
• Squalene epoxidase
• Candidiasis
• Aspergillosis
• Dermatophytosis

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