Alpha-Methylhistamine
Alpha-Methylhistamine (α-Methylhistamine) is a histamine derivative that acts as a selective agonist at the histamine H3 receptor. It is used in scientific research to investigate the function of this receptor.
Chemistry[edit | edit source]
Alpha-Methylhistamine is a derivative of histamine, a biogenic amine that is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. The addition of a methyl group to the alpha position of histamine results in Alpha-Methylhistamine.
Pharmacology[edit | edit source]
Alpha-Methylhistamine acts as a selective agonist at the histamine H3 receptor. Agonists are substances that bind to a certain receptor and cause a response in the cell. The histamine H3 receptor is one of the four known histamine receptors and is mainly found in the central nervous system.
Use in Research[edit | edit source]
Due to its selective action on the histamine H3 receptor, Alpha-Methylhistamine is used in scientific research to investigate the function of this receptor. Studies using this compound have contributed to our understanding of the role of histamine in the brain and its potential implications in conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
