Aprindine

Aprindine.svg

Aprindine' is a pharmaceutical drug used primarily as an antiarrhythmic agent. It is classified under the class I antiarrhythmic drugs, which work by blocking sodium channels in the heart to stabilize the cardiac membrane and prevent abnormal heart rhythms.

Mechanism of Action

Aprindine functions by inhibiting the fast sodium channels in the myocardial cells, which leads to a decrease in the rate of depolarization during the action potential. This action helps to stabilize the cardiac membrane and prevent the occurrence of arrhythmias. By slowing down the conduction velocity and prolonging the refractory period, aprindine helps to maintain a regular heart rhythm.

Clinical Uses

Aprindine is used in the management of various types of arrhythmias, including:

• Ventricular tachycardia
• Atrial fibrillation
• Atrial flutter
• Premature ventricular contractions

Side Effects

Common side effects of aprindine include:

• Dizziness
• Nausea
• Fatigue
• Visual disturbances

Serious side effects may include:

• Proarrhythmia
• Heart failure
• Hepatotoxicity

Pharmacokinetics

Aprindine is administered orally and is well absorbed from the gastrointestinal tract. It undergoes extensive hepatic metabolism and is excreted primarily through the urine. The half-life of aprindine is approximately 16-20 hours, allowing for twice-daily dosing.

History

Aprindine was developed in the mid-20th century and has been used in clinical practice for several decades. It is not as commonly used today due to the availability of newer antiarrhythmic agents with more favorable side effect profiles.

See Also

• Antiarrhythmic agent
• Sodium channel blocker
• Cardiac arrhythmia
• Ventricular tachycardia
• Atrial fibrillation