Aprindine

Aprindine is a Class 1B antiarrhythmic agent, a type of medication used to treat and prevent abnormal heart rhythms. It is not commonly used today due to the availability of safer and more effective alternatives.

Etymology[edit | edit source]

The term "Aprindine" is derived from the chemical name of the drug, which is 1-(3-[[2-(diethylamino)ethyl]amino]-2-hydroxypropyl)pyrindin-2-one.

Pharmacology[edit | edit source]

Aprindine works by blocking the fast inward sodium current, thereby slowing the rate of rise of the action potential and prolonging its duration. This results in a decrease in the excitability of the heart muscle, which can help to prevent abnormal heart rhythms.

Side Effects[edit | edit source]

Like all medications, Aprindine can cause side effects. These may include dizziness, nausea, vomiting, and changes in heart rate. In rare cases, it can cause more serious side effects such as heart failure or life-threatening heart rhythm disorders.

History[edit | edit source]

Aprindine was first synthesized in the 1960s and was widely used for the treatment of various heart rhythm disorders. However, its use has declined in recent years due to the development of safer and more effective antiarrhythmic drugs.

See Also[edit | edit source]

Aprindine Resources
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