Diethylpropion

From WikiMD's Wellnesspedia

Diethylpropion is a sympathomimetic amine and anorectic agent used for the treatment of obesity.

Background[edit | edit source]

Diethylpropion (dye eth" il proe' pee on) is a structural analogue to amphetamine and has similar activity in suppressing appetite, but has few of the other central nervous system effects of amphetamines and less abuse potential.

Approval for use[edit | edit source]

Diethylpropion was approved as a therapy for obesity in the United States in 1959 and is recommended only for short term use (less than 12 weeks).

Availability[edit | edit source]

Diethylpropion is available by prescription as 25 mg immediate release and 75 mg controlled release tablets in generic forms and formerly under the trade name Tenuate.

Dosage[edit | edit source]

The usual dose is 75 mg daily either as 25 mg (immediate release) 1 hour before meals or 75 mg (controlled release) once daily.

DEA schedule[edit | edit source]

Diethylpropion is a Schedule IV controlled substance, meaning that it has a proven but low potential for abuse and has an accepted medical use.

Side effects[edit | edit source]

  • Common side effects include nervousness, excitability, insomnia, headache, dry mouth, sweating, nausea, constipation, and thirst.
  • Rare severe adverse events include atrial fibrillation, acute psychosis and pulmonary hypertension.
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Contributors: Prab R. Tumpati, MD