Phentermine

Phentermine structure

Phentermine is controlled substance and an appetite suppressant weight loss medication or diet pill used as weight loss prescription that has been on the market for over 50 years in the United States.

FDA approval[edit]

Approved by the US FDA in 1959, Phentermine has been on the market for a long time with proven safety record. Phentermine is used for a limited period of time to speed weight loss in overweight people who are exercising and eating a low-calorie diet. Phentermine is in a class of medications called anorectics. It works by decreasing appetite. Phentermine comes as tablets and extended-release capsules. It usually is taken as a single daily dose in the morning or three times a day 30 minutes before meals.

Indications for Phentermine[edit]

ADIPEX-P® is a sympathomimetic amine anorectic weight loss medication indicated as a short-term adjunct in a regimen of weight decrease based on exercise, behavioral modification and caloric limit in the management of exogenous obesity for patients with:

Adipex P 37.5 mg

a primary body mass index ≥ 30 kg/m2, or
≥ 27 kg/m2 along with other risk factors such as controlled hypertension, metabolic syndrome, diabetes, hyperlipidemia etc.

Adverse effects of Phentermine[edit]

Phentermine is generally well tolerated and most people may not experience any major side effects.

Treatment should be discontinued inpatients who develop new, unexplained symptoms of dyspnea, angina pectoris, syncope or smaller extremity edema, and patients should be evaluated for the possible occurrence of pulmonary hypertension. Common (1% or more in incidence) adverse effects include:

Phentermine

Rare (1% or less incidence) adverse effects include:

Primary pulmonary hypertension
Valvular heart disease (in combination with dexfenfluramine and fenfluramine; causal relationship unclear)
Increased seizure activity in people with epilepsy
Psychosis
Withdrawal symptoms on stopping are rare
Dysphoria
Ischaemic events are rare

Cautions and interactions[edit]

Phentermine use is contraindicated in those who are:

Known hypersensitivity or idiosyncratic reaction to sympathomimetic amines
Taking amphetamine (i.e., Adderall, Dexedrine, Vyvanse), dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (e.g., phenelzine) in the last 14 days
Hyperthyroidism
Glaucoma
Peptic ulcer
Prostatic hypertrophy
Epilepsy
Simultaneous treatment with drugs that increase blood pressure
Contraindicated in cardiac disease (e.g. advanced arteriosclerosis, pulmonary hypertension, uncontrolled hypertension, arrhythmias) and cerebrovascular disease (stroke)
Pregnant, planning to become pregnant, or are breast-feeding
Those receiving serotonergic medications such as the selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitor, tricyclic antidepressant, due to the potential for serotonin syndrome to be precipitated by the treatment.

Weight loss medications

Since 2012, the FDA approved many new weight loss medications such as Qsymia, Saxenda, Contrave after years of rejecting many other weight loss medications. There are other traditional and time tested weight loss medications such as Phentermine, Phendimetrazine etc.

What works and what does not for losing weight?

New weight loss medications Qsymia and Wegovy

weight loss centers

Mechanism of action[edit]

It is believed to suppress the appetite and increases the metabolism by its actions on the appetite center

Dosing and administration[edit]

It is available in 15 mg, 30 mg and 37.5 mg in tablet and capsule form.

Brand names available[edit]

Adipex P (immediate release)
Anoxine-AM
Ionamin (slow-release resin, Australia, discontinued in the US)
Mirapront
Obephen
Obermine
Obestin-30
Phentermaxx
Phentrol
Phenterex
Phentromin
Pro-Fast SA
Qsymia (with topiramate)
Redusa
Panbesy
Phentermine Trenker
Obenix
Oby-Trim
Teramine
Zantryl
Suprenza (disintegrates orally)

Phentermine and Topiramate[edit]

Phentermine is often combined with Topiramate like in the brand name Qsymia for better weight loss results, mitigate some of the side effects, and increase effectiveness. In fact, in a large 30,000 patient diet pill comparison study published in JAMA that compared new prescription weight loss medications or diet pills, Qsymia was considered the most effective weight loss prescription medication.

WikiMD's weight loss clinic locator (USA)

Obesity is a complex health condition characterized by an excessive amount of body fat. Finding the right weight loss doctor is crucial for a successful obesity management plan. Need help finding a weight loss clinic in the United States that might be willing to prescribe Zepbound, Wegovy, Ozempic, Mounjaro, Saxenda or other weight loss medications such as Phentermine?

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poly 643 371 666 452 621 458 621 473 606 468 604 374 Weight loss in Alabama poly 152 457 153 540 177 548 205 576 205 589 183 588 158 553 117 547 100 567 12 578 66 547 41 517 52 469 72 449 107 437 Weight loss in Alaska poly 132 396 190 434 229 441 245 325 161 309 157 326 148 326 140 347 151 364 Weight loss in Arizona poly 490 346 489 404 499 419 551 419 566 373 574 353 560 347 Weight loss in Arkansas poly 27 164 91 181 73 243 140 339 138 346 149 363 134 394 91 389 41 334 13 194 Weight loss in California poly 257 235 369 248 364 331 247 320 Weight loss in Colorado poly 818 185 819 206 845 195 842 180 Weight loss in Connecticut

poly 794 239 799 270 813 270 808 255 Weight loss in Delaware

poly 731 453 776 545 757 583 739 584 714 520 688 472 663 485 624 471 624 460 666 454 666 460 Weight loss in Florida poly 644 368 686 364 736 417 730 455 668 457 Weight loss in Georgia poly 219 507 216 552 259 588 339 590 343 557 292 508 Weight loss in Hawaii poly 169 48 154 107 161 116 145 140 137 190 226 206 236 157 206 154 200 127 189 131 192 105 175 72 182 50 Weight loss in Idaho poly 555 221 539 263 563 291 560 304 582 330 595 328 605 291 601 227 591 209 552 215 Weight loss in Illinois poly 603 229 602 312 631 305 650 284 644 222 Weight loss in Indiana poly 461 197 454 215 469 258 535 258 544 244 553 225 540 198 Weight loss in Iowa poly 368 268 361 333 488 336 488 291 481 285 484 277 471 269 Weight loss in Kansas poly 581 343 677 330 697 310 682 289 652 281 633 309 602 313 Weight loss in Kentucky poly 504 488 510 458 498 440 501 421 553 421 555 435 546 461 574 461 585 475 593 499 547 504 Weight loss in Louisiana poly 836 111 850 149 854 157 897 106 887 89 872 60 849 56 Weight loss in Maine poly 732 253 732 263 756 254 778 266 776 275 788 278 798 296 811 268 797 268 793 242 Weight loss in Maryland poly 816 170 817 186 849 180 857 187 878 189 878 171 854 160 Weight loss in Massachusetts

poly 544 114 555 131 596 149 613 224 664 219 674 191 647 128 581 85 Weight loss in Michigan poly 448 79 456 143 453 147 461 156 461 196 541 196 541 186 513 168 510 150 520 126 556 96 483 86 478 71 Weight loss in Minnesota poly 568 376 603 373 606 472 585 473 573 459 546 459 556 427 555 415 Weight loss in Mississippi poly 470 259 471 269 486 288 488 345 566 344 561 353 571 353 582 334 559 305 562 294 536 261 Weight loss in Missouri poly 184 49 179 70 194 104 190 127 200 123 209 152 235 154 237 147 342 158 351 75 Weight loss in Montana poly 340 203 337 244 368 247 368 265 475 269 460 217 426 208 Weight loss in Nebraska poly 92 182 180 200 156 324 146 323 141 342 73 244 Weight loss in Nevada poly 829 114 825 168 852 160 835 109 Weight loss in New_Hampshire poly 801 207 799 225 806 231 797 240 809 254 823 224 815 218 815 211 Weight loss in New_Jersey

poly 245 320 347 330 337 436 245 431 242 443 226 439 Weight loss in New_Mexico poly 727 177 716 205 789 190 799 204 815 209 815 216 823 221 847 202 821 205 817 185 817 167 803 124 777 128 754 166 Weight loss in New_York poly 706 328 666 366 716 357 748 359 768 375 817 333 803 309 Weight loss in North_Carolina poly 351 76 345 138 455 144 447 80 Weight loss in North Dakota poly 653 281 679 285 686 292 714 243 710 213 675 224 663 220 645 223 649 275 Weight loss in Ohio poly 347 331 488 337 494 407 430 397 397 388 397 347 345 345 Weight loss in Oklahoma poly 60 79 26 145 26 162 136 188 142 137 157 118 150 104 99 104 73 97 72 83 Weight loss in Oregon poly 708 210 716 255 791 240 804 230 797 223 799 205 788 191 Weight loss in Pennsylvania poly 849 179 855 187 847 195 841 183 Weight loss in Rhode_Island

poly 686 363 738 418 765 376 749 361 716 356 Weight loss in South Carolina poly 346 138 456 144 452 149 459 157 459 195 456 214 425 207 375 202 341 201 343 182 343 160 Weight loss in South_Dakota poly 569 374 667 366 705 327 575 344 Weight loss in Tennessee poly 346 342 337 439 274 432 306 485 331 501 347 484 368 488 407 560 440 572 440 532 507 489 511 457 498 412 483 404 397 389 396 345 Weight loss in Texas poly 182 201 228 209 224 232 256 234 244 321 162 307 Weight loss in Utah poly 803 123 816 168 825 168 828 120 Weight loss in Vermont poly 698 310 677 331 803 308 789 280 775 276 778 267 765 258 753 258 731 277 726 304 Weight loss in Virginia poly 57 76 73 85 73 95 111 102 158 109 168 49 88 25 60 34 Weight loss in Washington poly 763 260 753 259 743 278 732 276 728 297 717 308 700 312 689 297 694 275 709 262 712 241 715 257 734 254 734 262 753 253 761 254 Weight loss in West_Virginia

poly 522 129 520 140 513 146 513 169 538 184 539 210 549 216 592 210 600 156 593 153 585 143 548 126 538 120 Weight loss in Wisconsin poly 239 148 223 232 337 244 343 157 Weight loss in Wyoming

rect 883 272 953 290 Weight loss in Delaware rect 882 291 951 315 Weight loss in Maryland rect 675 33 785 60 Weight loss in New_Hampshire rect 867 244 950 269 Weight loss in New_Jersey rect 680 88 774 113 Weight loss in Massachusetts rect 871 222 955 243 Weight loss in Connecticut rect 848 316 955 339 Weight loss in Washington_DC rect 858 340 953 361 Weight loss in West_Virginia rect 727 63 780 86 Weight loss in Vermont rect 863 195 954 220 Weight loss in Rhode_Island

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