3,4-Methylenedioxyphentermine

A psychoactive drug of the phenethylamine and amphetamine classes

3,4-Methylenedioxyphentermine
INN
Drug class
Routes of administration	Oral
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status	Uncontrolled
CAS Number	32052-16-3
PubChem	4436
DrugBank
ChemSpider	4283
KEGG

3,4-Methylenedioxyphentermine (MDPH) is a psychoactive drug of the phenethylamine and amphetamine chemical classes. It is structurally related to 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA), which are well-known recreational drugs.

Chemical structure and properties

3,4-Methylenedioxyphentermine is a derivative of amphetamine with a methylenedioxy group attached to the phenyl ring. The chemical formula is C₁₀H₁₃NO₂, and it has a molecular weight of 179.22 g/mol. The presence of the methylenedioxy group is thought to contribute to its psychoactive properties.

Pharmacology

MDPH acts as a central nervous system stimulant. It is believed to exert its effects by increasing the release of neurotransmitters such as dopamine, norepinephrine, and serotonin in the brain. This action is similar to that of other amphetamines and is responsible for its stimulant and empathogenic effects.

Effects

The effects of 3,4-methylenedioxyphentermine are not well-documented, but it is thought to produce effects similar to those of MDA and MDMA, including increased energy, euphoria, and enhanced sensory perception. However, due to limited research, the full range of effects and potential risks are not well understood.

Legal status

3,4-Methylenedioxyphentermine is not a controlled substance in most jurisdictions, but its structural similarity to other controlled substances may subject it to regulation under analogue laws.

Synthesis

The synthesis of MDPH involves the reaction of safrole with methylamine in the presence of a reducing agent. This process is similar to the synthesis of other methylenedioxy-substituted amphetamines.

Related compounds

• 3,4-Methylenedioxyamphetamine (MDA)
• 3,4-Methylenedioxymethamphetamine (MDMA)
• 3,4-Methylenedioxy-N-ethylamphetamine (MDEA)

See also

• Phenethylamine
• Amphetamine
• Psychoactive drug

Related pages

• List of psychedelic drugs
• List of entactogens

3,4-Methylenedioxyphentermine

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