3,4-Methylenedioxyamphetamine

3,4-Methylenedioxyamphetamine (MDA), also known as tenamfetamine or Sally, is a psychoactive drug used primarily as a recreational drug, but also for psychotherapy and neuropharmacology research. It is a member of the amphetamine family and is chemically similar to both methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA).

Chemistry[edit | edit source]

MDA is a substituted amphetamine, specifically a methylenedioxy derivative. It is formed by replacing the hydrogen atom in the amphetamine molecule's alpha carbon with a methylenedioxy group. This results in a compound with increased potency and psychoactive effects.

Pharmacology[edit | edit source]

MDA acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA), increasing the levels of these neurotransmitters in the brain. It also acts as a serotonin receptor agonist, further enhancing its psychoactive effects. MDA's effects are thought to be primarily due to its action on the serotonin transporter.

Effects[edit | edit source]

The effects of MDA can include euphoria, increased sociability, heightened sensory perception, and hallucinations. These effects can last for several hours, and are often followed by a period of fatigue and depression.

Risks[edit | edit source]

MDA use carries several risks, including neurotoxicity, hyperthermia, dehydration, and serotonin syndrome. Chronic use can lead to drug dependence and withdrawal symptoms.

Legal status[edit | edit source]

MDA is classified as a Schedule I controlled substance in the United States, meaning it has a high potential for abuse and no accepted medical use. It is also illegal in many other countries.