3,4-Methylenedioxyamphetamine

3,4-Methylenedioxyamphetamine (MDA), also known as tenamfetamine or Sally, is a psychoactive drug used primarily as a recreational drug, but also for psychotherapy and neuropharmacology research. It is a member of the amphetamine family and is chemically similar to both methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA).

Chemistry

MDA is a substituted amphetamine, specifically a methylenedioxy derivative. It is formed by replacing the hydrogen atom in the amphetamine molecule's alpha carbon with a methylenedioxy group. This results in a compound with increased potency and psychoactive effects.

Pharmacology

MDA acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA), increasing the levels of these neurotransmitters in the brain. It also acts as a serotonin receptor agonist, further enhancing its psychoactive effects. MDA's effects are thought to be primarily due to its action on the serotonin transporter.

Effects

The effects of MDA can include euphoria, increased sociability, heightened sensory perception, and hallucinations. These effects can last for several hours, and are often followed by a period of fatigue and depression.

Risks

MDA use carries several risks, including neurotoxicity, hyperthermia, dehydration, and serotonin syndrome. Chronic use can lead to drug dependence and withdrawal symptoms.

Legal status

MDA is classified as a Schedule I controlled substance in the United States, meaning it has a high potential for abuse and no accepted medical use. It is also illegal in many other countries.

See also

• Amphetamine
• Methamphetamine
• 3,4-methylenedioxymethamphetamine (MDMA)
• Psychoactive drug
• Recreational drug use