MMDA (drug)

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Synonyms
MMDA (drug)
Drug Information
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KEGG ChEBI

IUPAC Name

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MMDA (3-methoxy-4,5-methylenedioxyamphetamine) is a psychoactive drug that belongs to the amphetamine class. It is also known as "Adam" or "Sass" in recreational settings. MMDA is structurally similar to MDMA (ecstasy) and MDA, but it has distinct effects and pharmacological properties.

History[edit | edit source]

MMDA was first synthesized by the American chemist Alexander Shulgin in the 1960s. Shulgin extensively studied the compound and documented its effects in his book PiHKAL (Phenethylamines I Have Known and Loved). MMDA gained popularity in the 1970s as a recreational drug, often used in combination with other substances like LSD or marijuana.

Pharmacology[edit | edit source]

MMDA acts primarily as a serotonin-norepinephrine-dopamine releasing agent (SNDRA), meaning it increases the levels of these neurotransmitters in the brain. It also has mild agonist activity at serotonin receptors. The exact mechanism of action and the full range of effects of MMDA are not yet fully understood.

Effects[edit | edit source]

The effects of MMDA are similar to those of other entactogens, such as MDMA. Users typically experience feelings of euphoria, increased empathy, and enhanced sensory perception. MMDA is also known to produce mild hallucinogenic effects, including visual distortions and color enhancement. The duration of the effects can last between 4 to 8 hours, depending on the dose and individual metabolism.

Risks and Side Effects[edit | edit source]

As with any psychoactive substance, MMDA carries certain risks and potential side effects. These can include increased heart rate, elevated blood pressure, dehydration, and hyperthermia. MMDA may also cause psychological effects such as anxiety, paranoia, and panic attacks. Prolonged or excessive use of MMDA can lead to neurotoxicity and long-term cognitive impairments.

Legal Status[edit | edit source]

The legal status of MMDA varies from country to country. In most jurisdictions, MMDA is classified as a controlled substance due to its psychoactive properties. Its production, distribution, and possession are generally illegal without proper authorization. It is important to note that the laws surrounding MMDA and other similar substances are subject to change, so it is advisable to consult local regulations before engaging in any activities involving MMDA.

See Also[edit | edit source]

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD