2,5-Dimethoxy-4-methylamphetamine

2,5-Dimethoxy-4-methylamphetamine (DOM), also known as STP (Serenity, Tranquility, and Peace), is a psychedelic drug and a member of the amphetamine family. It was first synthesized and documented in 1963 by Alexander Shulgin, a renowned American medicinal chemist and psychopharmacologist.

Chemistry

DOM is a derivative of mescaline and is chemically classified as a phenethylamine, specifically a substituted amphetamine. Its full chemical name is 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. The drug is usually found in the form of a white powder, but it can also be pressed into tablets or capsules.

Pharmacology

DOM acts as a potent partial agonist for the 5-HT2A receptor, which is thought to be its primary site of action in producing its psychedelic effects. It also has affinity for the 5-HT2B and 5-HT2C receptors. The effects of DOM are thought to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Effects

The effects of DOM can be unpredictable and vary greatly among individuals. They can include both physical and psychological effects. Physical effects can include pupil dilation, increased heart rate, increased blood pressure, sweating, and nausea. Psychological effects can include feelings of euphoria, visual hallucinations, changes in perception, anxiety, and paranoia.

History and usage

DOM was first synthesized by Alexander Shulgin in 1963. In the mid-1960s, it was distributed under the name "STP" in the form of tablets. This led to a number of hospitalizations due to its high potency and long duration of action. The negative publicity resulted in the scheduling of the drug in the United States in 1970.

Legal status

In the United States, DOM is classified as a Schedule I controlled substance, meaning it has a high potential for abuse and no accepted medical use. It is also illegal in many other countries under various drug control laws.

See also

• Psychedelic drug
• Amphetamine
• Alexander Shulgin
• 5-HT2A receptor

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