Jimscaline

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Jimscaline

Jimscaline is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and documented in his book PiHKAL.

Chemistry

Jimscaline, or 4-methoxy-3,5-dimethoxyphenethylamine, is a molecule of the phenethylamine class. Phenethylamines are a family of compounds containing a phenethylamine skeleton, which consists of a phenyl ring bound to an amino (NH2) group through an ethyl chain. Jimscaline contains three methoxy functional groups CH3O- which are attached to carbons R4 and R3 of the phenyl ring and R5 of the phenethylamine backbone.

Pharmacology

The mechanism that produces the hallucinogenic and entheogenic effects of Jimscaline is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.

Effects

The effects of Jimscaline are reported to be similar to those of other psychedelic phenethylamines, but with a significantly longer duration. Users report an altered sense of time, visual hallucinations, and changes in thought processes.

Legality

As of 2021, Jimscaline is not a controlled substance in any country, but its production, sale, or possession could potentially be prosecuted under the Federal Analog Act in the United States because of its structural similarities to other controlled phenethylamines such as 2C-B and 2C-I.

See also

• Phenethylamine
• Psychedelics, dissociatives and deliriants
• PiHKAL
• Alexander Shulgin