4-Methylamphetamine

4-Methylamphetamine (4-MA) is a stimulant drug related to amphetamine and methamphetamine. It is a member of the phenethylamine and amphetamine chemical classes.

Chemistry

4-Methylamphetamine is a substituted amphetamine. Its structure is comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R⁴. It is a chiral compound and both of its enantiomers are equally potent as stimulants.

Pharmacology

4-Methylamphetamine acts as a releasing agent and reuptake inhibitor of dopamine, norepinephrine, and serotonin. This leads to an increase in the concentration of these three neurotransmitters in the synaptic cleft, resulting in increased stimulation of their respective receptors.

Effects

The effects of 4-Methylamphetamine are similar to those of other stimulants and include euphoria, increased alertness, increased energy, and increased sociability. However, it also has a higher risk of causing neurotoxicity and cardiotoxicity compared to other amphetamines.

Legal Status

In many countries, 4-Methylamphetamine is a controlled substance due to its potential for abuse and addiction. It is classified as a Schedule II controlled substance in the United States under the Controlled Substances Act.

See Also

• Amphetamine
• Methamphetamine
• Phenethylamine

References

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