GLP-1 receptor agonist

GLP-1 receptor agonists are a group of medications used in the treatment of type 2 diabetes and obesity. They work by mimicking the functions of the natural glucagon-like peptide-1 (GLP-1) in the body, which is involved in glucose metabolism and appetite regulation.

Mechanism of Action

GLP-1 receptor agonists work by binding to the GLP-1 receptor, which is found on the surface of certain cells in the pancreas. This binding stimulates the release of insulin, a hormone that helps regulate blood sugar levels. In addition, GLP-1 receptor agonists slow down the rate at which the stomach empties, which can help control appetite and lead to weight loss.

Uses

GLP-1 receptor agonists are primarily used in the treatment of type 2 diabetes. They can be used alone or in combination with other diabetes medications. Some GLP-1 receptor agonists are also approved for the treatment of obesity.

Side Effects

Common side effects of GLP-1 receptor agonists include nausea, vomiting, diarrhea, and constipation. In rare cases, they can cause pancreatitis, a serious inflammation of the pancreas.

Examples

Examples of GLP-1 receptor agonists include exenatide (Byetta), liraglutide (Victoza), dulaglutide (Trulicity), and semaglutide (Ozempic).

See Also

• Type 2 diabetes
• Obesity
• Insulin
• Pancreas
• Exenatide
• Liraglutide
• Dulaglutide
• Semaglutide