Glucagon-like peptide-1

From WikiMD's Food, Medicine & Wellnesspedia

Glucagon-like Peptide-1 (GLP-1)[edit | edit source]

Principals funcions GLP-1

Glucagon-like peptide-1 (GLP-1) is a hormone that is secreted from the intestines in response to food intake. It plays a crucial role in the regulation of blood glucose levels and has been implicated in the pathophysiology of type 2 diabetes.

Glucagon-like Peptide-1 (GLP-1) is an incretin hormone that plays a critical role in glucose metabolism, insulin secretion, and appetite regulation. Produced in the intestinal L cells and certain neurons within the brain, GLP-1 is a key player in the enteroinsular axis, mediating the increase in insulin secretion in response to nutrient intake. This article delves into the physiological functions of GLP-1, its therapeutic applications, particularly in the treatment of type 2 diabetes mellitus and obesity, and highlights recent research in the field.

Physiological Role[edit | edit source]

GLP-1 exerts multiple actions on glucose homeostasis and gastrointestinal function:

  • Insulin Secretion: Enhances insulin secretion from pancreatic β-cells in a glucose-dependent manner, preventing hyperglycemic spikes post-meal.
  • Gastric Emptying: Slows gastric emptying, aiding in the reduction of postprandial glucose levels.
  • Appetite Regulation: Acts on the brain to promote satiety and reduce food intake, contributing to weight management.
  • Glucagon Suppression: Inhibits glucagon secretion, thereby reducing hepatic glucose production.
Illustration of insulin and glucagon regulation in glucose metabolism.

Therapeutic Uses[edit | edit source]

GLP-1's role in enhancing insulin secretion and promoting satiety has led to the development of GLP-1 receptor agonists for managing type 2 diabetes and obesity:

  • Type 2 Diabetes Mellitus: GLP-1 receptor agonists, such as exenatide and liraglutide, improve glycemic control by enhancing insulin secretion and suppressing glucagon release.
  • Obesity: These agents reduce appetite and food intake, leading to significant weight loss in patients with obesity.

GLP-1 Receptor Agonists[edit | edit source]

GLP-1 receptor agonists mimic the action of endogenous GLP-1, offering several benefits:

  • Improved glycemic control with a low risk of hypoglycemia
  • Weight reduction
  • Potential cardiovascular benefits

Function[edit | edit source]

GLP-1 is secreted by L cells in the intestine in response to food intake. It acts on the pancreas to stimulate insulin secretion and inhibit glucagon secretion, thereby helping to regulate blood glucose levels. GLP-1 also slows gastric emptying and promotes satiety, which can help to control body weight.

Role in disease[edit | edit source]

Impaired GLP-1 secretion and action have been implicated in the pathophysiology of type 2 diabetes. GLP-1-based therapies, such as GLP-1 receptor agonists and DPP-4 inhibitors, are currently used in the treatment of this disease.

Therapeutic use[edit | edit source]

GLP-1-based therapies are used in the treatment of type 2 diabetes. These include GLP-1 receptor agonists, which mimic the action of GLP-1, and DPP-4 inhibitors, which prevent the breakdown of GLP-1. These therapies can help to improve blood glucose control and promote weight loss.

See also[edit | edit source]

References[edit | edit source]

Glucagon-like peptide-1 Resources
Doctor showing form.jpg

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski

Transform Your Life with W8MD Weight Loss Centers[edit source]

W8MD weight loss doctors team

W8MD offers a physician-supervised weight loss program at various locations including New York, Pennsylvania and New Jersey. Our centers provide expert medical guidance, accept most insurances, and offer telemedicine options for convenience.

Why choose W8MD?[edit source]

Book Your Appointment[edit source]

Start your weight loss journey today at our centers in New York, New Jersey and Pennsylvania and visit Call (718)946-5500


Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.