4-Methylphenylisobutylamine

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1-(4-Methylphenyl)-2-aminobutane

4-Methylphenylisobutylamine, also known as 4-Methyl-α-ethylphenethylamine or 4-MEAI, is a psychoactive drug and research chemical belonging to the phenethylamine class of compounds. It is known for its stimulant and entactogenic effects, similar to those of MDMA (ecstasy), but with potentially less pronounced empathogenic effects. The chemical structure of 4-Methylphenylisobutylamine is closely related to other phenethylamines, making it part of a larger family of compounds that affect the central nervous system by interacting with neurotransmitter receptors, particularly those involved in the release and reuptake of serotonin, dopamine, and norepinephrine.

Chemistry[edit | edit source]

4-Methylphenylisobutylamine is a synthetic molecule of the phenethylamine family. Its chemical formula is C11H17N, indicating it has eleven carbon atoms, seventeen hydrogen atoms, and one nitrogen atom. The molecule consists of a phenethylamine backbone with an isobutyl group attached to the alpha carbon and a methyl group attached to the fourth carbon of the benzene ring. This structural modification is thought to influence its pharmacological properties, making it distinct from other phenethylamines.

Pharmacology[edit | edit source]

The pharmacological action of 4-Methylphenylisobutylamine is primarily characterized by its stimulant and entactogenic effects. It is believed to work by increasing the release of neurotransmitters such as serotonin, dopamine, and norepinephrine in the brain, which are responsible for its mood-elevating and stimulatory effects. However, the exact mechanism of action remains less understood compared to more extensively studied compounds like MDMA.

Effects[edit | edit source]

Users of 4-Methylphenylisobutylamine report a range of subjective effects, including increased energy, euphoria, enhanced sensory perception, and feelings of social connectedness. However, like all psychoactive substances, it also poses risks of adverse effects, including anxiety, paranoia, and potential neurotoxicity, especially with frequent or high-dose use.

Legal Status[edit | edit source]

The legal status of 4-Methylphenylisobutylamine varies by country, with some jurisdictions classifying it as a controlled substance, thereby restricting its manufacture, distribution, and possession. In other areas, it remains unregulated, existing in a legal gray area as a research chemical.

Safety and Toxicology[edit | edit source]

Due to its status as a research chemical, comprehensive studies on the safety, toxicity, and long-term effects of 4-Methylphenylisobutylamine are limited. Potential users should exercise caution and be aware of the legal and health risks associated with its use.



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Contributors: Prab R. Tumpati, MD